To exploit genome knowledge requires lots of money

A dozen years ago the human genome map started to become available. We remain at the front door in exploiting that genetic knowledge. Individuals have had access to their own genetic map. Scientists have made steady but modest advances in exploring the genetic basis of all sorts of diseases. Much of the advances that have been made and will continue to accelerate have capitalized on the efficiency of genetic mapping and the associated drop in the cost of uncovering genetic information.

Longevity is the latest big picture theme under investigation via the use of genetic information. Craig Venter, the investigator who was the first to map the human genome, is planning to sequence genomes in order to uncover how people can live longer and healthier lives. To do that he started a new company called Human Longevity. That company plans to process 40,000 human genomes a year. Wow!! The plan is to combine data on the health and body composition of the people whose DNA is sequenced. With that information in the bank it may be possible to shed light on the molecular causes of aging and age-related illnesses like cancer and heart disease. With that information it may be possible to slow aging and prevent many diseases, especially those associated with the aging process.

There are other players in this arena that are using genomic technology to understand issues related to health and disease. For example, Regeneron Pharmaceuticals will sequence 100,000 human genomes.

The pay off from this research can be enormous but…..how long do we want to live, and what are the consequences of preventing diseases, and who will social security go bust trying to sustain all us oldies.

Along with the uncovering the genetic scripts that define so much of our selves we are also now have tools for editing and rewriting our genetic diary. Some of the startling new properties of some bacteria can be used to alter our genetic scripts. It is all amazing beyond words.